Wellbutrin and Alcohol

Many people wonder about the side effects of taking Wellbutrin and drinking alcohol. Wellbutrin® (bupropion) is a commonly prescribed antidepressant. A daily medication to combat depressive symptoms of various mood disorders.

  • Taking Wellbutrin while drinking alcohol is dangerous.

Despite this, many people taking Wellbutrin also drink alcohol for social or recreational purposes. Because of this, it’s common for people taking the drug to ask whether drinking alcohol while on Wellbutrin is acceptable? While doctors may act with abundant caution in many medical situations, this is not one of them.

Several factors make this combination of drugs and alcohol very risky. Due to this, the exact consequences will differ for each person.

However, because the worst consequences can result in serious illness, and there is no way to determine the implications for any individual, all people should avoid drinking while on Wellbutrin.

This combination is primarily dangerous because they are both CNS-active compounds. Because both compounds act on the central nervous system, increasing the other’s intensity or effects.

In layman’s terms, this means that Wellbutrin makes the effects of alcohol more potent and vice versa.

  • The effects of alcohol increase by the fact Wellbutrin reduces alcohol tolerance.

Because of this, individuals drinking and on Wellbutrin will suffer from the effects of alcohol after consuming less alcohol than usual, and those effects will be stronger than average.

In addition to heightening the side effects, mixing this drug with alcohol results in another problem because Wellbutrin is an antidepressant and alcohol is a depressant.

When both compounds are in the system, they cancel each other out. As a result, people who mix these are likely to experience an episode of depression. In the worst-case scenario, this can lead to serious self-harm.


One of the most severe side effects of Wellbutrin is seizures. Therefore, doctors who prescribe this drug are usually cautious with dosage to minimize this side effect and don’t prescribe it to people already in danger of attacks.

Side effects

Combining alcohol with Wellbutrin, the side effects increase like all the others. In addition, it is hazardous because most people prescribed this drug are not familiar with dealing with seizures, which means that a sudden episode can result in serious injury due to a lack of familiarity.

Common side effects include:

  • Seizures
  • Dizziness
  • Blackouts
  • Nausea
  • Vomiting
  • Confusion
  • Impaired judgment
  • Paranoia
  • Overdosing

Call 911 immediately at the first signs of an overdose.

As with all overdoses, medical attention is critical. An overdose of alcohol or Wellbutrin can result in severe repercussions like organ damage, coma, or worse.

As previously noted, because both compounds increase the strength of each other, it is possible to overdose on Wellbutrin or alcohol, or both at the same time. Even if only on the prescribed dosage and only modest amounts of alcohol have been consumed.