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Dolo 650 – OTC Pain Reliever

Dolo 650 is an over-the-counter medication commonly used to relieve mild to moderate pain and reduce fever. Its active ingredient is paracetamol (acetaminophen), known for its pain-relieving and fever-reducing properties.

It is a round, white tablet that is scored down the middle. It can be taken with or without food, although taking it with food may reduce the risk of stomach upset. They are typically packaged in blister packs and are white in color.

The patient package insert contains valuable information, including its indications, ingredients, quantity, and possible side effects.

  • It’s important to note that if you have any allergies or sensitivities to any of the ingredients, it is advisable to consult with a healthcare professional before taking it.

It is a brand of paracetamol that works by blocking the production of certain chemicals in the body that can cause pain and inflammation. Exceeding the recommended dosage can be dangerous as it can overload the liver’s ability to metabolize it.


This medication is primarily used for relieving mild to moderate pain and reducing fever. It can effectively treat conditions such as headaches, toothaches, menstrual cramps, backaches, arthritis, muscle aches, sprains, and elevated temperature from infections such as colds and flu. It may also help with reducing sleeplessness and sinus discomfort.


While paracetamol is generally considered safe when taken as directed, taking excessive amounts can lead to liver damage, which can be life-threatening. It is important to exercise caution if you have a history of ulcers, asthma, or other respiratory conditions. Individuals with liver or kidney disease, anemia, or alcoholism should avoid it or consult with a healthcare provider before taking it. It is crucial to adhere to the recommended dosage, avoid combining it with other drugs containing paracetamol, and not exceed a maximum duration of 10 days without consulting a healthcare provider.

Side Effects

The most common side effects are mild and temporary, including nausea, vomiting, stomach ache, headache, and dizziness. However, if you experience any allergic or adverse reactions, discontinue use immediately and seek medical attention.


Overdosing is serious. Symptoms may include nausea, vomiting, abdominal issues, yellowing of the skin and eyes (jaundice), kidney and liver failure, and coma. The maximum recommended amount for adults is 4 grams per day (1 gram per pill, up to 4 per day). Certain factors such as chronic alcoholism, malnutrition, and medical conditions can increase the risk of overdose. If an overdose is suspected, seek immediate medical attention. Prevention includes following the recommended dosage on the packaging, avoiding exceeding the maximum recommended quantity, and keeping it out of reach of children.


Studies have shown the effectiveness of paracetamol in treating acute lower backaches and osteoarthritis. However, it has been found to be less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for these conditions. Another study demonstrated its efficacy in reducing elevated temperature in children with acute respiratory tract infections, although children receiving paracetamol were more likely to experience issues such as vomiting and diarrhea compared to those receiving ibuprofen.

Prevalence in the Population

According to the World Health Organization (WHO), paracetamol is widely used worldwide and plays a crucial role in managing symptoms associated with various infections, including colds, flu, and COVID-19.

How It Works

Paracetamol works by blocking the production of prostaglandins, which are substances that trigger pain and inflammation in the body. It is also believed to affect the part of the brain that regulates body temperature, helping to lower elevated temperatures by reducing the production of prostaglandins in the brain.

History and Popularity

Introduced in the United States in 1955, paracetamol quickly gained popularity due to its safety profile. It is widely used in India and other countries to alleviate mild to moderate discomfort and fever. It is available under various brand names worldwide, including the United States.