Can Zoloft And Other Antidepressants Get Users “High”?

zoloft package

Zoloft is a selective serotonin reuptake inhibitor (SSRI). It is an antidepressant prescribed for depression, general anxiety, panic and obsessive-compulsive disorder. By retaining adequate levels of serotonin in the brain, Zoloft helps to regulate;

  • mood
  • sleep
  • negative thought patterns
  • abnormal compulsions/impulses

In addition to Prozac, Effexor and Lexapro;

  • Zoloft is one of the most prescribed antidepressants in the U.S.

zoloft pills in handZoloft works slowly to regulate serotonin levels in the brain and may take several weeks to provide relief from depression and anxiety. Unlike street drugs or prescription opioids that provide an immediate “high”, Zoloft’s mood-moderating properties may not be felt by some users for at least five to six weeks.

Antidepressant Abuse

According the National Institute of Health: “…while antidepressants are generally thought to have low abuse liability, there is evidence in the literature of their misuse, abuse, and dependence.  “The majority of reported cases of antidepressant abuse occur in individuals with co- morbid substance use and mood disorders.”

High on Zoloft

Zoloft and all other antidepressants will not give you the same kind of a “high” associated with psychoactive drugs like marijuana, benzodiazepines or heroin.

No. Zoloft is meant to reduce symptoms of depression, anxiety and OCD.

  • No matter how much Zoloft you take, you will not feel the analgesic, euphoric and/or stimulating effects you feel from abusing opioids or amphetamines.


Standard dosage for treating depression, obsessive-compulsive disorder and social anxiety start at 50 mg daily.

Therefore, taking more than 200 mg a day puts users at risk for suffering severe side effects requiring emergency medical intervention.

Possible Side Effects

In fact, taking too much Zoloft could cause one or more of the following adverse side effects:

  • Agitation
  • Fever
  • Muscle spasms
  • Nosebleed
  • Incontinence
  • Tachycardia (racing heartbeat)
  • Itchy hives or rashes anywhere on the body
  • Uncontrollable facial or body movements


Yes, of course, overdosing on Zoloft may also make you suddenly lose consciousness as serotonin and other neurotransmitters flood the brain and disrupt nerve signaling.

  • However, Zoloft overdose fatalities are extremely rare, with most deaths occurring because users combined Zoloft with alcohol or other medications.

Combining Zoloft with Marijuana or Alcohol


Zoloft intensifies the intoxicating effects of alcohol, especially on psychomotor functioning (walking, standing, reaction times) and mood.

  • People combining alcohol and Zoloft may behave aggressively or irrationally, and become suicidal and engage in risky, impulsive behavior.


According to FDA reports, studies have investigated the side effects of mixing Zoloft with marijuana. Results found the following:

  • After combining Zoloft with marijuana for one month, users began feeling extremely anxious, thought about suicide and suffered from chronic joint pain. Some also said they felt euphoric but angry at the same time.
  • People smoking marijuana while taking Zoloft for six months reported dizziness, stomach pain, weakness, tremors, eye pain and diarrhea.
  • Zoloft users smoking pot for one year suffered suicidal ideation, dissociative disorder and anger/aggression.

Zoloft With Opioids

In 2016, the FDA issued boxed warnings against taking medications containing hydrocodone and oxycodone with Zoloft. This warning alerts Zoloft users of the dangers of mixing Zoloft with potent pain medications due to the ability of both drugs to suppress central nervous system functions. Side effects of combining prescription opioids with Zoloft include;

  • respiratory depression
  • extreme sleepiness
  • coma
  • possible death

More Resources

SSRI Research