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Pliva 434 Pills

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Pliva 434 are round, white pills containing trazodone hydrochloride. Each tablet has engraving on one side and an indentation on the other for splitting them in half.

This drug belongs to the classification of SARI (Serotonin antagonist and reuptake inhibitors). Peak concentrations in the blood are reached within approximately 1 hour if taken on an empty stomach or 2 hours after eating.

Indications

Pliva 434 treats the following conditions:

  • Depression
  • Sedation

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PropertyInformation
NamePliva 434
Ingredients100 mg of trazodone
Indicationsdepression, sedation
ContraindicationsHeart, MAOI & others*
Side EffectsDizzy, drowsy, headache & others
Drug ClassSARI
AvailabilityPrescription
AdministrationOral
MarkingsNumbers, scored
ColorWhite
ShapeRound
Size11.00 mm
CSA ClassificationNot a controlled-substance
WarningsSuicidal ideation, liver, withdrawal
Mechanism of Actioninhibiting serotonin transporter, type-2 receptors
PackagingBottle
StorageDark, cool
PregnancyRisk
FDA ApprovedYes
SupplierTEVA
Brand NamesDesyrel, Oleptro

Mechanism

Experts suggest that this medicine is an antidepressant that works by inhibiting both the serotonin transporter and serotonin type-2 receptors. It inhibits the reuptake of serotonin and blocks the histamine and alpha-1-adrenergic receptors. However, the full spectrum of its mechanism of action is not entirely understood, which explains its off-label uses.

Interactions

Other medicines can decrease its effect, influence how long it works for, or have less effect when taken with this medication. Common medications that may interact with it include:

  • Anticonvulsants
  • Antipsychotics
  • Any substance that may cause drowsiness
  • Other antidepressants
  • Warfarin

Side effects

Commonly reported side effects include:

  • Blurred vision
  • Dizziness
  • Drowsiness
  • Headache
  • Constipation
  • Sexual dysfunction
  • Nausea and vomiting
  • Dry mouth
  • Liver damage

Contraindications and precautions include:

  1. Hypersensitivity to Trazodone: Individuals who have had an allergic reaction to trazodone in the past should avoid taking it.
  2. Concurrent Use with MAOIs: Trazodone should not be used within 14 days of taking monoamine oxidase inhibitors (MAOIs). There’s a risk of serotonin syndrome if trazodone is combined with MAOIs.
  3. Serotonin Syndrome: Care should be taken when combining trazodone with other medications that increase serotonin levels, such as SSRIs, SNRIs, triptans, tramadol, and some others. This combination can lead to serotonin syndrome, a potentially life-threatening condition.
  4. Cardiac Conditions: Trazodone can affect the heart’s rhythm. It’s crucial for individuals with certain cardiac conditions or those on medications that can affect the heart’s rhythm to discuss with their healthcare provider before starting trazodone.
  5. Suicidal Thoughts and Behaviors: All antidepressants, including trazodone, come with a warning about the risk of suicidal thoughts and behaviors, especially in children, adolescents, and young adults.
  6. Priapism: Trazodone has been associated with a rare condition called priapism (a prolonged, painful erection). This is a medical emergency and requires immediate treatment.
  7. Angle-Closure Glaucoma: There have been cases of people developing angle-closure glaucoma after starting trazodone. Those with a history of this eye condition should be cautious.
  8. Hyponatremia (Low Sodium): Trazodone can cause or exacerbate low sodium levels in the blood, especially in elderly individuals or those taking diuretics.
  9. Bleeding Events: Trazodone might increase the risk of bleeding, especially when taken with other drugs that can increase bleeding risk, such as aspirin, NSAIDs, or anticoagulants.

Remember, this is not an exhaustive list. It’s essential for anyone considering taking trazodone or any other medication to consult with their doctor or pharmacist, who can provide guidance tailored to the individual’s health and other medications they may be taking.

Liver

The liver and kidneys process it, so special care is necessary for individuals with severe hepatic and kidney impairments. In addition, idiopathic drug-induced liver injury may result from administration. It usually occurs with long-term administration (typically three months), but reported cases have required liver transplantation.

Sleep

This medication also treats insomnia as an off-label use in adults. Off-label refers to uses that are not FDA-approved but may still be prescribed by your doctor if deemed necessary. Only generic forms are available, making it cheaper than other sleep-inducing alternatives. However, it may cause withdrawal symptoms (see below) upon discontinuation.

Addiction

Pliva 434 pils are considered to be non-addictive. Therefore, it’s not a controlled substance under the Controlled Substances Act (CSA).

Withdrawal

When the time comes to stop taking this medicine, withdrawal should be medically managed. The dosage is gradually reduced under a doctor’s supervision. If stopped abruptly, it may cause a discontinuation syndrome which manifests with the following symptoms:

  • Anxiety
  • Agitation
  • Sleep disturbances

Serotonin Syndrome

This medication may also increase serotonin and cause a severe condition called Serotonin Syndrome. While rare, serotonin syndrome is potentially life-threatening. The risk is higher if you take other medications that increase serotonin. Seek medical help immediately if you develop any of the following symptoms:

  • Mental status changes [such as agitation, hallucinations, coma, delirium]
  • Fast heart rate
  • Dizziness
  • Flushing
  • Muscle tremor or rigidity
  • Unexplained fever
  • Unusual agitation/restlessness
  • Stomach symptoms (including nausea, vomiting, and diarrhea)

Alcohol

Avoid drinking alcohol or taking illegal or recreational substances while taking it.

Brand names include:

  • Desyrel
  • Oleptro

Label

See also 433

Read about the drug g037.