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Pliva 433 Round White Pills

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Pliva 433 is a generic form of trazodone hydrochloride. It is an oral, prescription medication to treat depression. It also treats the anxiety, psychological symptoms of fibromyalgia, and insomnia attributed to depression. Each pill treats major depressive disorder (MDD) in adults only. In addition, trazodone can improve mood, increase energy levels, and enhance appetite for some people. Croatian pharmaceutical is the manufacturer.

  • Each Pliva 433 tablet contains 50 mg of trazodone.
pliva433 front and back on blue background

Side effects

Possible side effects are similar to those of most antidepressants, including:

  • Nausea
  • Diarrhea or constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Muscle aches

This drug may cause heart palpitations, rapid heartbeat, migraine, or visual disturbances.

  • Dosage amounts may need adjustment to stop more severe side effects.

After taking this drug for about six to eight weeks, side effects should diminish considerably.


According to the FDA, suggestions are as follows;

  • Take shortly after a meal or light snack.
  • Tablets should be swallowed whole or broken in half along the scoreline.
  • When discontinued, reduce the dose gradually. Otherwise, there is the risk of antidepressant discontinuation syndrome (ADS). Many patients suffer from this syndrome due to non-adherence to the therapy.
  • Trazodone’s main ingredient is hydrochloride salt. It has antidepressant and sedative properties.


It is not physically or psychologically addicting. If you suddenly stop taking trazodone after taking the medication for several months. In that case, you could suffer antidepressant discontinuation syndrome (ADS) resulting from the brain trying to adjust to reduced serotonin levels. ADS signs include extreme dizziness, anxiety, insomnia, and flu-like symptoms that make some users feel pretty ill.

Serotonin Syndrome

A potentially severe serotonin syndrome may cause agitation, headache, vomiting, fast heartbeat, and profuse sweating if taken with other SSRIs. It happens when too much serotonin floods the brain. Severe cases of serotonin syndrome may require emergency treatment. Treatment includes forced diuresis (stomach pumping) or activated charcoal administration to counteract the brain’s toxic serotonin levels.


  • The FDA approved it in 1981.
  • This drug was also the first non-tricyclic antidepressant approved in the United States.
  • Each contains hydrochloride.
  • They were first manufactured in Italy by Angelini Research Labs in the 1960s.
  • They are considered second-generation antidepressants. Other second-generation antidepressants include Bupropion, Viloxazine, and Iprindole.
  • Overdosing is rare.


In the latest studies, it is now in a new category. Hence the complete mechanism of action is yet unknown. They act by antagonizing serotonin receptors and inhibiting the reuptake of serotonin, norepinephrine, or dopamine. This action relieves depression and anxiety by preventing receptors on specific brain cells.

  • They are a Selective Serotonin Reuptake Inhibitors (SSRI).
  • Serotonin is a primary neurotransmitter for moderating mood, sleep, appetite, motivation, and libido.
  • There is a line down the middle to help split them in half.

Second-generation antidepressants have fundamentally similar chemical structures and pharmacological effects. At the time, researchers developed this drug according to studies indicating that depression emerged due to a person’s inability to feel pain. However, in contrast to other antidepressants at that time, it exerted minimal effects on particular neurotransmitter receptors involved in depression.


  • Although developed initially for treating depression, this drug is also prescribed “off-label” as a sleep aid.

When drugs are prescribed off-label, doctors prescribe them for purposes not approved by the FDA. As a result, off-label prescription use is the drug’s proven effectiveness for a particular health issue. The U.S. DEA does NOT list trazodone as a controlled substance since it does not act on the “reward” center like opioids and alcohol.

National Drug Code

The National Drug Code (NDC) is a division of the FDA. All drugs get a unique, three-digit number called the National Drug Code (NDC), which the FDA uses for identification.

National Drug Code# Pills per Bottle