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AN 627 White Round Pills

AN 627 are oval, white pills containing Tramadol. It is an opioid analgesic drug prescribed by physicians to relieve acute or chronic pain. Sometimes drowsiness, sedation, and dizziness occur before the pain decreases. How well people tolerate this drug is determined primarily by their age, weight, health, and other factors.

It is the opioid affecting receptors that control pain sensations, sedation, and to some extent, mood. As a result, some people may doze off for a short time using tramadol, while others could lapse into a lengthier sleep.

Active Ingredient

  • Tramadol hydrochloride 50 mg


Tramadol Hydrochloride Tablets USP, 50 mg are supplied as scored, white, round film-coated tablets debossed “AN” over “627” on one side and plain on the other side.


Tramadol hydrochloride tablets are indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Key Data Points – Table

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IngredientsTramadol 50 mg
IndicationsModerate to severe pain
Contraindicationsrespiratory depression, asthma, concurrent use of monoamine MAOIs and others
Drug classCentrally acting analgesic
AvailabilityPrescription only
Onset of action30 to 60 minutes
Markingsdebossed “AN” over “627”
CSA classificationSchedule IV
Warningssee box
Mechanism of actionAgonist mu-opioid receptor, inhibits the reuptake of norepinephrine and serotonin in the CNS
StorageCool, dark, dry place
FDA approvedYes
Brand namesUltram, Ultracet
NDC code65162-627

Mechanism of Action

Tramadol’s mechanism of action is unique and has two main components:

  1. Mu-opioid receptor agonism: Tramadol acts as agonists at the mu-opioid receptor. This is similar to other opioids, like morphine. Binding to these receptors leads to analgesic effects, but also to potential side effects typical of opioids, such as respiratory depression, dependence, and euphoria.
  2. Inhibition of neurotransmitter reuptake: Unlike many other opioids, tramadol inhibits the reuptake of norepinephrine and serotonin in the central nervous system. This can enhance inhibitory effects on pain transmission in the spinal cord. This mechanism is somewhat similar to the action of certain antidepressants, specifically the serotonin-norepinephrine reuptake inhibitors (SNRIs).

The combination of these two mechanisms provides tramadol with its unique analgesic profile. It’s worth noting that due to the serotonin uptake inhibition, tramadol has a potential risk of causing serotonin syndrome, especially when combined with other serotonergic drugs.

As with all medications, the use of tramadol requires a careful consideration of benefits and risks, and its prescription and usage should be under the guidance of a healthcare professional.


Physicians prescribe tramadol for moderate pain usually between 50 mg and 100 mg. Exceeding your doctor’s recommended dosage could cause serious side effects and signs of an overdose.


There are multiple warnings and contraindications for this drug; see details. Users must tell their doctor if they take antidepressants, anxiety medication, other opioids, amphetamines, or antibiotics. Interaction between Tramadol and any of these drugs could cause adverse side effects requiring emergency medical treatment.

Side Effects

Since it is an opioid pain reliever, users will experience side effects similar to other opioid analgesics. Side effects can include:

  • mental fog
  • drowsiness
  • sedation
  • decreased alertness
  • body numbness
  • euphoria
  • dizziness

Other adverse side effects could include the following:

  • Nausea and vomiting
  • Dry mouth
  • Stomach cramps
  • Indigestion
  • Vertigo
  • Headache
  • Constipation
  • Itchiness


Tramadol can also act as an antidepressant because it keeps higher serotonin and norepinephrine levels in the brain. Also, Tramadol binds to opioid receptors like morphine and heroin to induce intense pain relief.


The liver further converts tramadol into a potent opioid called desmetramadol. Desmetramadol is a legal substitute for street and pharmaceutical opioids. A blend of synthetic desmetramadol and Kratom goes by “Krypton.” Unfortunately, Krypton has been the cause of several overdose deaths in the past few years.


Tramadol hydrochloride tablets contain tramadol, a Schedule IV controlled substance. As an opioid, tramadol hydrochloride exposes users to the risks of addiction, abuse, and misuse.

As an opioid, abuse and addiction are serious concerns. Tramadol is a controlled substance listed by the DEA as Schedule IV. The following statistics are per the National Survey on Drug Use and Health for 2016;

  • 1.6 million people in the U.S. aged 12 or older misused tramadol products in the past year.

Tramadol is a popular prescription medication. According to the DEA;

  • 43.6 million tramadol prescriptions in the U.S. in 2016.
  • 16.0 million prescriptions in the first half of 2018.


Mixing this drug with alcohol is dangerous and increases the intensity and accelerates the side effects. According to the government’s website Medline, “Drinking alcohol while taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment can be dangerous.”

Drinking alcohol while on tramadol increases the risk of experiencing the serious, life-threatening side effects listed below. Therefore, do not drink alcohol, take prescription or nonprescription medications that contain may alcohol. Also, do not use street drugs during treatment.

NDC code

The National Drug Code :65162-627

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