Mixing Melatonin and Alcohol – Interactions – Side Effects

Alcohol and Medicine illustration on white background

Melatonin and alcohol: Melatonin is a hormone the body naturally produces, particularly at night. Its function is to regulate the body’s sleep-wake cycle or circadian rhythm and to promote restful sleep. Melatonin is available as a synthetic supplement in pill form and in a sublingual form, you place under your tongue. Are melatonin and alcohol safe to use together? Find out what impact drinking alcohol can have on melatonin levels and whether the two are safe to take at the same time.

About Melatonin

Melatonin is popular as a sleep aid. It’s also used to readjust the sleep-wake cycle in people with jet lag related to travel across time zones. Although studies are limited, there is some evidence that melatonin helps the symptoms of jet lag and modestly improves sleep quality. Some small studies suggest that taking melatonin as a supplement may decrease the time it takes to fall asleep. Melatonin supplements may also be beneficial for people who do shift work as it helps regulate the body’s sleep-wake cycle.

Melatonin and Alcohol Interactions

Many people assume that because melatonin is a natural supplement that it’s safe. However, supplements can interact with other supplements, with food, and with alcohol – and melatonin is no exception. Drinking alcohol while taking melatonin can potentially lead to undesirable side effects. Since melatonin is a hormone that helps regulate sleep, a common side effect is drowsiness. Alcohol, especially at higher doses, causes sleepiness and drowsiness as well.

  • Therefore, melatonin and alcohol in combination may have additive effects and lead to increased sedation

These side effects are particularly risky for people who work a job that requires them to be awake and alert.

Not Worth Taking A Fall

Since alcohol potentially enhances the sedative effects of melatonin, drinking alcohol with this antibiotics may also increase the risk of falls and injuries. Melatonin alone may cause these possible adverse side effects such as;

  • mild headache
  • irritability
  • fatigue
  • mild feelings of depression or sadness
  • dizziness
  • lightheadedness
  • problems walking

Combining melatonin and even more alcohol may enhance or magnify these  potentially debilitating side-effects.


Avoid combining melatonin and booze. It can interact with supplements, including this drug, in unexpected ways and in ways that aren’t clearly understood yet.

While some studies suggest that alcohol increases melatonin levels, others show that alcohol reduces circulating melatonin. So, taking melatonin and drinking liquor together could theoretically reduce the sleep-enhancing benefits of melatonin and make the supplement less beneficial. More research is needed to determine the impact melatonin and drinking have on each other. The effects may vary with the dosage of melatonin, alcohol dosage, the timing of each, and individual variations in how each is metabolized or broken down.



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