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Pregabalin, the main ingredient in Lyrica, produces psychoactive effects comparable to the euphoric and sedative effects produced by other central nervous system suppressants such as Xanax or Valium. However, these effects tend to diminish over time unless the user starts taking more Lyrica than prescribed.
Combining Lyrica with antidepressants, antihistamines, anti-anxiety medications, narcotic pain medications and alcohol is known to enhance the psychoactive effects of Lyrica.
Lyrica has been designated a Schedule V medication by the U.S. Drug Enforcement Agency. Drugs considered to have a lower potential for abuse and addiction than pain medications listed as Schedule II, III or IV are placed under Schedule 5.
No reports of Lyrica overdose events have be substantiated that we’re aware of.
Lyrica, aka pregabalin, is approved by the U.S. FDA to treat a variety of painful nerve conditions such as fibromyalgia, migraines diabetic neuropathy, shingles, anxiety disorders and partial onset epileptic seizures in adults (who are already taking drugs for seizures). Lyrica is a central nervous system depressant and a GABAergic anticonvulsant that does not bind to benzodiazepine, opioid or certain GABA receptors to provide pain, seizure and anxiety relief. Instead, Lyrica appears to increase the amount of GABA transporter proteins and extracellular GABA by producing more L-glutamic acid decarboxylase, an enzyme implicated in the development of schizophrenia, bipolar disorder, diabetes, Parkinson’s disease and neuropathic pain.
Sleepiness and dizziness are the two most reported side effects of taking Lyrica. In clinical studies comparing a placebo with Lyrica, 30 percent of subjects taking Lyrica suffered dizziness and sleepiness while only eight percent of placebo patients reported similar effects. Other side effects of taking Lyrica reported in clinical studies include:
Rare, but possible are allergic reactions which may occur when taking Lyrica. Allergic reaction symptoms can include:
Any of these symptoms are indicative of a serious allergic reaction requiring immediate medical treatment.
Like other anti-seizure, anti-epileptic drugs, Lyrica carries a risk of causing suicidal ideation or actions in a small number of people. Lyrica may worsen existing depression, panic disorders and anxiety to the point that a Lyrica user may contemplate suicide. Other severe reactions to Lyrica include acting aggressively or violently, mania (nonstop talking or activity), extreme mood changes and dangerous impulsivity.
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