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Can Zoloft Get You High

Can Zoloft get you high? Let’s examine this point in detail. Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI). It is an antidepressant prescribed for;

  • depression
  • general anxiety disorder
  • panic disorder
  • obsessive-compulsive disorder

How it works

Before increasing the amount, this interval of time is due to its slow onset of action. Its mode of action is to stop the reuptake of serotonin. It manipulates nerve cells in the brain so that more serotonin is available for transmission between nerves. Other neurotransmitters affect mood, but SSRIs are ‘selective’ for serotonin.

It has also been FDA-approved for post-traumatic stress disorder (PTSD) in female civilian patients, although most doctors will use it for female and male adult patients. It is the brand name for the drug sertraline. It is one of the most popular prescribed antidepressants in the U.S.


The National Institute of Health (NIH) states antidepressant abuse is part of the non-medical use of prescription medications. “The scope of antidepressant misuse is unknown, …there is evidence in the literature of their misuse, abuse, and dependence.”

  • Zoloft (sertraline) is not a controlled substance.
  • Antidepressant abuse is not uncommon.

According to the National Institute of Health, “…while people think antidepressants have low abuse liability, there is evidence in the literature of their misuse, abuse, and dependence. In addition, most reported cases of antidepressant abuse occur in individuals with co-morbid substance use and mood disorders.”

  • Zoloft and other antidepressants will not give you the same kind of “high” associated with psychoactive drugs like marijuana, benzodiazepines, or heroin.
  • No matter how much you take, you will not feel the analgesic, euphoric, and stimulating effects of opioids or amphetamines.

Please do not stop your SSRI suddenly because it can cause withdrawal syndrome. Instead, talk to your doctor to gradually and safely decrease your dose.

Withdrawal symptoms can include:

  • A general feeling of uneasiness
  • Nausea
  • Dizziness
  • Lethargy
  • Flu-like symptoms


According to the CDC, “During 2015–2018, 13.2% of adults used antidepressants in the past 30 days. Use was higher among women (17.7%) than men (8.4%).”

Retaining adequate levels of serotonin in the brain helps regulate:

  • mood
  • sleep
  • negative thought patterns
  • abnormal compulsions/impulses

The answer to how long it takes for Zoloft to work is prolonged. It regulates serotonin levels in the brain and may take several weeks to relieve depression and anxiety. Don’t expect to feel much of a change immediately. A slight reduction in symptoms may occur in the first week or so. It will probably be somewhere from two to six weeks before the effects of the Zoloft are complete.

  • Some users may not complete its mood-moderating properties for at least four weeks or even longer.
  • It takes time to adapt to the significant increase in serotonin levels in the brain.

It could cause one or more of the following side effects:

  • Nausea, vomiting, diarrhea
  • Tired, exhausted
  • Headache
  • Agitation
  • Dry mouth
  • Drowsiness
  • Insomnia
  • Nervousness, agitation, restlessness
  • Weight gain or weight loss from appetite changes
  • Sexual dysfunction

Of course, overdosing may also cause serotonin syndrome, which can cause fever, sweating, confusion, tremors, lack of coordination, significant changes in blood pressure, and a rapid heart rate. However, overdose fatalities are extremely rare, with most deaths occurring because users combine them with alcohol or other drugs.


This drug intensifies the intoxicating effects of alcohol, especially on psychomotor functioning (walking, standing, reaction times) and mood. As a result, people combining alcohol and Zoloft may behave aggressively or irrationally, become suicidal, and engage in risky, impulsive behavior.


Studies have investigated the side effects of mixing it with marijuana. Results found the following:

  • After combining it with weed for one month, users began feeling extremely anxious, thought about suicide, and suffered from chronic joint pain. Some also said they felt euphoric but angry at the same time.
  • People smoking marijuana while taking it for six months reported dizziness, stomach pain, weakness, tremors, eye pain, and diarrhea.
  • Users smoking pot for one year suffered suicidal ideation, dissociative disorder, and anger or aggression.


In 2016, the FDA issued boxed warnings against taking medications containing hydrocodone and oxycodone. This warning alerts users of the dangers of mixing it with potent pain medications due to both drugs’ ability to suppress central nervous system functions. Side effects of combining prescription opioids with it include;

  • respiratory depression
  • extreme sleepiness
  • coma
  • possible death

Black Box Warning

All antidepressants carry a BLACK BOX WARNING label, the strictest warning by the FDA that they risk causing suicidal ideation, especially in children and teenagers.

Zoloft is a Registered Trademark.